English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The emergence of SARS-CoV-2 variants of concern endangers the long-termcontrol of COVID-19, especially in countries with limited genomic surveillance.In this work, we explored genomic drivers of contagion in Chile. We sequenced3443 SARS-CoV-2 genomes collected between January and July 2021, where theGamma (P.1), Lambda (C.37), Alpha (B.1.1.7), B.1.1.348, and B.1.1 lineages werepredominant. Using a Bayesian model tailored for limited genomic surveillance,we found that Lambda and Gamma variants' reproduction numbers were about 5% and16% larger than Alpha's, respectively. We observed an overabundance ofmutations in the Spike gene, strongly correlated with the variant'stransmissibility. Furthermore, the variants' mutational signatures featured abreakpoint concurrent with the beginning of vaccination (mostly CoronaVac, aninactivated virus vaccine), indicating an additional putative selectivepressure. Thus, our work provides a reliable method for quantifying novelvariants' transmissibility under subsampling (as newly-reported Delta,B.1.617.2) and highlights the importance of continuous genomic surveillance.

Mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants