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Acoustic impedance mismatches between soft tissues and bones are known toresult in strong aberrations in optoacoustic and ultrasound images. Ofparticular importance are the severe distortions introduced by the human skull,impeding transcranial brain imaging with these modalities. While modelling ofultrasound propagation through the skull may in principle help correcting forsome of the skull-induced aberrations, these approaches are commonly challengedby the highly heterogeneous and dispersive acoustic properties of the skull andlack of exact knowledge on its geometry and internal structure. Here wedemonstrate that the spatio-temporal properties of the acoustic distortionsinduced by the skull are preserved for signal sources generated at neighboringintracranial locations by means of optoacoustic excitation. This optoacousticmemory effect is exploited for building a three-dimensional model accuratelydescribing the generation, propagation and detection of time-resolved broadbandoptoacoustic waveforms traversing the skull. The memory-based model-basedinversion is then shown to accurately recover the optical absorptiondistribution inside the skull with spatial resolution and image qualitycomparable to those attained in skull-free medium.

High resolution transcranial imaging based on the optoacoustic memory effect