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Dynamic positron emission tomography (dPET) is currently a widely usedmedical imaging technique for the clinical diagnosis, staging and therapyguidance of all kinds of human cancers. Higher temporal imaging resolution forthe early stage of radiotracer metabolism is desired; however, in this case,the reconstructed images with short frame durations always suffer from alimited image signal-to-noise ratio (SNR) and unsatisfactory image spatialresolution. The appearance of uEXPLORER (United Imaging Healthcare, Inc.) withhigher PET imaging sensitivity and resolution may help solving this problem. Inthis work, based on dynamic PET data acquired by uEXPLORER, we proposed a dPETprocessing method that denoises images with short frame durations viapixel-level time-activity curve (TAC) correction based on third-order Hermiteinterpolation (Pitch-In). The proposed method was validated and compared toseveral state-of-the-art methods to demonstrate its superior performance interms of high temporal resolution dPET image noise reduction and imagingcontrast. Higher stability and feasibility of the proposed Pitch-In method forfuture clinical application with high temporal resolution (HTR) dPET imagingcan be expected.

High temporal resolution total-body dynamic PET imaging based on pixel-level time-activity curve correction