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With the ongoing global pandemic of coronavirus disease 2019 (COVID-19),there is an increasing quest for more accessible, easy-to-use, rapid,inexpensive, and high accuracy diagnostic tools. Traditional disease diagnosticmethods such as qRT-PCR (quantitative reverse transcription-PCR) and ELISA(enzyme-linked immunosorbent assay) require multiple steps, trainedtechnicians, and long turnaround time that may worsen the disease surveillanceand pandemic control. In sight of this situation, a rapid, one-step,easy-to-use, and high accuracy diagnostic platform will be valuable for futureepidemic control especially for regions with scarce medical resources. Herein,we report a magnetic particle spectroscopy (MPS) platform for detection ofSARS-CoV-2 biomarkers: spike and nucleocapsid proteins.

One-step, Wash-free, Nanoparticle Clustering-based Magnetic Particle  Spectroscopy (MPS) Bioassay Method for Detection of SARS-CoV-2 Spike and  Nucleocapsid Proteins in Liquid Phase