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Interstitial connective tissues are one of the four basic types of animaltissue and continuously distributed throughout the body. Illustrated by themovements of the micron-sized particles across the defined tissue boundariesand the continuously distributions of the fluorescently stained hyaluronic acidwithin the fibrous tissues around blood vessels and nerves, the authors of thispaper suggested that interstitial fluid (ISF) is not fixed locally but wouldflow through fibrous matrices for a long-distance, even between more distantparts of the body. However,the fluid-filled interstitial spaces are similarwith the interstitial tissue channel, lacking a distinct spatial structure for"free" interstitial fluid flow, which might be the key to comprehend thewhereabouts and directions of a systemic fluid flow and circulation.

Commentaries on the publication entitled Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans