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The application of metal nanoparticles as sensitization materials is a commonstrategy that is used to study dose enhancement in radiotherapy. Recent invitro tests have revealed that magnetic gold nanoparticles can be used incancer therapy under a magnetic field to enhance the synergistic efficiency inradiotherapy and photothermal therapy. However, magnetic gold nanoparticleshave rarely been studied as sensitization materials. In this study, we obtainedfurther results of the sensitization properties of magnetic gold nanoparticlesusing the Monte Carlo method TOPAS and TOPAS-nBio. We analyzed the propertiesof magnetic gold nanoparticles in monoenergetic photons and brachytherapy, andwe investigated whether the magnetic field contributes to the sensitizationprocess. Our results demonstrated that the dose enhancement factor of themagnetic gold nanoparticles was 16.7% lower than that of gold nanoparticles ina single particle irradiated by monoenergetic photons. In the cell model, thedifference was less than 8.1% in the cytoplasm. We revealed that the magneticfield has no detrimental effect on radiosensitization. Moreover, thesensitization properties of magnetic gold nanoparticles in a clinicalbrachytherapy source have been revealed for the first time.

Investigation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS simulation