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Background: Robotic technologies involved in skin laser are emerging.Objective: To compare the accuracy, efficacy and safety of novel roboticprototype with human operator in laser operation performance for skinphoto-rejuvenation. Methods: Seventeen subjects were enrolled in a prospective,comparative split-face trial. Q-switch 1064nm laser conducted by the roboticprototype was provided on the right side of the face and that by theprofessional practitioner on the left. Each subject underwent a single time,one-pass, non-overlapped treatment on an equal size area of the forehead andcheek. Objective assessments included: treatment duration, laser irradiationshots, laser coverage percentage, VISIA parameters, skin temperature and theVAS pain scale. Results: Average time taken by robotic manipulator was longerthan human operator; the average number of irradiation shots of both sides hadno significant differences. Laser coverage rate of robotic manipulator (60.2+-15.1%) was greater than that of human operator (43.6 +-12.9%). The VISIAparameters showed no significant differences between robotic manipulator andhuman operator. No short or long-term side effects were observed with maximumVAS score of 1 point. Limitations: Only one section of laser treatment wasperformed. Conclusion: Laser operation by novel robotic prototype is morereliable, stable and accurate than human operation.

A Split-face Study of Novel Robotic Prototype vs Human Operator in Skin Rejuvenation Using Q-switched Nd:Yag Laser: Accuracy, Efficacy and Safety