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The latest advances in computer-assisted precision medicine are making itfeasible to move from population-wide models that are useful to discoveraggregate patterns that hold for group-based analysis to patient-specificmodels that can drive patient-specific decisions with regard to treatmentchoices, and predictions of outcomes of treatment. Body Composition isrecognized as an important driver and risk factor for a wide variety ofdiseases, as well as a predictor of individual patient-specific clinicaloutcomes to treatment choices or surgical interventions. 3D CT images areroutinely acquired in the oncological worklows and deliver accurate renderingof internal anatomy and therefore can be used opportunistically to assess theamount of skeletal muscle and adipose tissue compartments. Powerful tools ofartificial intelligence such as deep learning are making it feasible now tosegment the entire 3D image and generate accurate measurements of all internalanatomy. These will enable the overcoming of the severe bottleneck that existedpreviously, namely, the need for manual segmentation, which was prohibitive toscale to the hundreds of 2D axial slices that made up a 3D volumetric image.Automated tools such as presented here will now enable harvesting whole-bodymeasurements from 3D CT or MRI images, leading to a new era of discovery of thedrivers of various diseases based on individual tissue, organ volume, shape,and functional status. These measurements were hitherto unavailable therebylimiting the field to a very small and limited subset. These discoveries andthe potential to perform individual image segmentation with high speed andaccuracy are likely to lead to the incorporation of these 3D measures intoindividual specific treatment planning models related to nutrition, aging,chemotoxicity, surgery and survival after the onset of a major disease such ascancer.

Comprehensive Validation of Automated Whole Body Skeletal Muscle,  Adipose Tissue, and Bone Segmentation from 3D CT images for Body Composition  Analysis: Towards Extended Body Composition