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Mitochondrial diseases are largely caused by dysfunction in mitochondrialproteins. However, annotations of human mitochondrial proteins are scatteredacross various public databases and individual studies. To facilitate researchaimed at elucidating mitochondrial functions, we constructed theMEGADOCK-Web-Mito database as a protein-protein interaction (PPI) predictiondata archive, including prediction results for exhaustive protein pairs of 654mitochondria-related human proteins. MEGADOCK-Web-Mito enables users to searchfor all PPI prediction results efficiently and comprehensively. In particular,we linked functional annotations to each human mitochondrial protein. Thecomprehensive and specialized human mitochondrial PPI prediction results andsearching function of MEGADOCK-Web-Mito will support further research onmitochondria and mitochondrial diseases.

MEGADOCK-Web-Mito: human mitochondrial protein-protein interaction prediction database