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Purpose: To develop and validate a multi-parametric SAturation-recoverysingle-SHot Acquisition (mSASHA) cardiac T1 and T2 mapping technique with highaccuracy and precision in a single breath-hold.  Methods: The mSASHA acquisition consists of 9 images in an 11 heartbeatbreath-hold -- the first without preparation, 6 images with saturation recoverypreparation, and 2 images with both saturation recovery and T2-preparation. T1and T2 values were calculated using a 3-parameter model. mSASHA was validatedin simulations and phantoms on a Siemens 3T Prisma scanner with comparison to ajoint T1-T2 technique with a 4-parameter model. mSASHA values were compared toreference MOLLI, SASHA and T2p-bSSFP sequences in 10 healthy volunteers.  Results: mSASHA had high accuracy compared to reference spin-echomeasurements, with an average of -0.7+/-0.4% T1 error and -1.3+/-1.3% T2 error.mSASHA coefficient of variation (CoV) in phantoms for T1 was lower than MOLLI(0.7+/-0.1% vs 0.9+/-0.2%, p<0.01) and similar to reference T2p-bSSFP for T2(1.4+/-0.6% vs 1.5+/-0.5%, p>0.05). In simulations, 3-parameter mSASHA fittinghad higher precision than 4-parameter joint T1-T2 fitting for both T1 and T2.In-vivo myocardial mSASHA T1 was similar to conventional SASHA (1523+/-18 ms vs1520+/-18 ms, p>0.05) with similar CoV to both MOLLI and SASHA (3.3+/-0.6% vs3.1+/-0.6% and 3.3+/-0.5% respectively, p>0.05 for both). Myocardial mSASHA T2values were 37.1+/-1.1 ms with similar precision to T2p-bSSFP (6.7+/-1.7% vs6.0+/-1.6%, p>0.05).  Conclusion: mSASHA provides high accuracy cardiac T1 and T2 quantification ina single breath-hold, with similar precision to reference MOLLI and linearT2p-bSSFP reference techniques.

Improved Accuracy and Precision In Simultaneous Myocardial T1 and T2 mapping with Multi-Parametric SASHA (mSASHA)