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Using a total of $5.25~{\rm fb}^{-1}$ of $e^{+}e^{-}$ collision data withcenter-of-mass energies from 4.236 to 4.600 GeV, we report the firstobservation of the process $e^{+}e^{-}\to \eta\psi(2S)$ with a statisticalsignificance of $5\sigma$. The data sets were collected by the BESIII detectoroperating at the BEPCII storage ring. We measure the yield of events integratedover center-of-mass energies and also present the energy dependence of themeasured cross section.

Observation of $e^{+}e^{-}\rightarrow\eta\psi(2S)$ at center-of-mass energies from 4.236 to 4.600 GeV