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Therapeutic protons acting on O18-substituted thymidine increase cytotoxicityin radio-resistant human cancer cells. We consider here the physics behind theirradiation during proton beam therapy and diagnosis using O18-enriched thyminein DNA, with attention to the effect of the presence of thymine-18 on cancercell death.

Using thymine-18 for enhancing dose delivery and localizing the Bragg peak in proton-beam therapy