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Biosensors are frequently used nowadays for the sake of their attractivecapabilities. Because of their high accuracy and precision, they are more andmore used in the medical sector. Natural receptors are mostly used, but theiruse have some specific drawbacks. Therefore, new read-out methods are beingdeveloped where there is no need for these receptors. Via a Transient PlaneSource (TPS) sensor, the thermal properties of a fluid can be determined. Thesesensors can detect the capability of a fluid to absorb heat i.e. the thermaleffusivity. By the way of monitoring this property, many potential bioprocessescan be monitored. The use of this promising technique was further developed inthis research for later use of detecting cell growth and proteinconcentrations. Firstly, the thermal properties of growth medium and yeastcells were determined. Here, it became clear that the thermal properties changein different concentrations. Also, measurements were performed on proteinconcentration. No unambiguously results were obtained from these tests. But,the overall results from the use of this sensor are very promising, especiallyin the cell detection compartment. However, further research will tell aboutthe applicability and sensitivity of this type of sensor.

Detecting cell and protein concentrations by the use of a thermal based sensor