English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is aradiotherapy based on compact accelerator neutron sources requiring anepithermal neutron field for tumour irradiations. Neutrons of 10 keV areconsidered as the maximum optimised energy to treat deep-seated tumours. Weinvestigated, by means of Monte Carlo simulations, the epithermal range from 10eV to 10 keV in order to optimise the maximum epithermal neutron energy as afunction of the tumour depth.  Methods: A Snyder head phantom was simulated and mono-energetic neutrons with4 different incident energies were used: 10 eV, 100 eV, 1 keV and 10 keV.$^{10}$B capture rates and absorbed dose composition on every tissue werecalculated to describe and compare the effects of lowering the maximumepithermal energy. The Therapeutic Gain (TG) was estimated considering thewhole brain volume.  Results: For tumours seated at 4 cm depth, 10 eV, 100 eV and 1 keV neutronsprovided respectively 54 $\%$, 36 $\%$ and 18 $\%$ increase on the TG comparedto 10 keV neutrons. Neutrons with energies between 10 eV and 1 keV providedhigher TG than 10 keV neutrons for tumours seated up to 6.4 cm depth inside thehead. The size of the tumour does not change these results.  Conclusions: Using lower epithermal energy neutrons for AB-BNCT tumourirradiation could improve treatment efficacy, delivering more therapeutic dosewhile reducing the dose in healthy tissues. This could lead to new Beam ShapeAssembly designs in order to optimise the BNCT irradiation.

On the Eptihermal Neutron Energy Limit for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT): Study and Impact of New Energy Limits