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It has been found that the effect of childhood trauma (CT) exposure may passon to the next generation. Scientists have hypothesized that the associationbetween CT exposure and placental-fetal stress physiology is the mechanism. Astudy was conducted to examine the hypothesis. To examine the associationbetween CT exposure and placental corticotrophin-releasing hormone (pCRH),linear mixed effect model and hierarchical Bayesian linear model wereconstructed. In Bayesian inference, by providing conditionally conjugatepriors, Gibbs sampler was used to draw MCMC samples. Piecewise linear mixedeffect model was conducted in order to adjust to the dramatic change of pCRH ataround week 20 into pregnancy. Pearson residual, QQ, ACF and trace plots wereused to justify the model adequacy. Likelihood ratio test and DIC were utilizedto model selection. The association between CT exposure and pCRH duringpregnancy is obvious. The effect of CT exposure on pCRH varies dramaticallyover gestational age. Women with one childhood trauma would experience 11.9%higher in pCRH towards the end of pregnancy than those without childhoodtrauma. The increase rate of pCRH after week 20 is almost four-fold larger thanthat before week 20. Frequentist and Bayesian inference produce similarresults. The findings support the hypothesis that the effect of CT exposure onpCRH over GA exists. The effect changes dramatically at around week 20 intopregnancy.

A Study on the Association between Maternal Childhood Trauma Exposure and Placental-fetal Stress Physiology during Pregnancy