English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

TASEP modeling was shown to offer a parsimonious explanation for theexperimentally confirmed ability of a single upstream Open Reading Frames(uORFs) to upregulate downstream translation during the integrated stressresponse. As revealed by numerical simulations, the model predicts thatreducing the density of scanning ribosomes upstream of certain uORFs increasesthe flow of ribosomes downstream. To gain a better insight into the mechanismwhich ensures the non-monotone relation between the upstream and downstreamflows, in this work, we propose a phenomenological deterministic modelapproximating the TASEP model of the translation process. We establish theexistence of a stationary solution featuring the decreasing density along theuORF for the deterministic model. Further, we find an explicit non-monotonerelation between the upstream ribosome density and the downstream flow for thestationary solution in the limit of increasing uORF length and increasinglyleaky initiation. The stationary distribution of the TASEP model, thestationary solution of the deterministic model and the explicit limit arecompared numerically.

A deterministic model for non-monotone relationship between translation of upstream and downstream open reading frames