English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Detection of small cancer biomarkers with low molecular weight and a lowconcentration range has always been challenging yet urgent in many clinicalapplications such as diagnosing early-stage cancer, monitoring treatment anddetecting relapse. Here, a highly enhanced plasmonic biosensor that canovercome this challenge using atomically thin two-dimensional (2D) phase changenanomaterial is developed. By precisely engineering the configuration withatomically thin materials, the phase singularity has been successfully achievedwith a significantly enhanced lateral position shift effect. Based on ourknowledge, it is the first experimental demonstration of a lateral positionsignal change > 340 {\mu}m at a sensing interface from all optical techniques.With this enhanced plasmonic effect, the detection limit has beenexperimentally demonstrated to be 10-15 mol L-1 for TNF-{\alpha} cancer marker,which has been found in various human diseases including inflammatory diseasesand different kinds of cancer. The as-reported novel integration of atomicallythin Ge2Sb2Te5 (GST) with plasmonic substrate, which results in a phasesingularity and thus a giant lateral position shift, enables the detection ofcancer markers with low molecular weight at femtomolar level. These resultswill definitely hold promising potential in biomedical application and clinicaldiagnostics.

Targeted Sub-attomole Cancer Biomarker Detection based on Phase Singularity 2D Nanomaterial-enhanced Plasmonic Biosensor