English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The theoretical study of deformability of special sequence of DNA doublehelix TATA-box is presentated. The paper elaborates on the mechanisms ofabnormal deformation of DNA TATA-box double helix that cannot be explainedusing the standard mechanical model of polymer molecules (WLC) and needs moredetailed modeling. Analyzing of DNA TATA-box deformation it is shown themolucule can undergo significant deformations due to its property of thestructural polymorphism, that is, possibility of the double helix fragment toexist in more then one conformations. In addition to elastic components(bending, twisting), the presented model includes the following deformationfeatures: possibility of conformation rearrangement of the shapes of the sugarrings, effects of a specific nucleotide sequence and anisotropy, the couplingbetween components. Presented model allows describe abnormal deformation basedon physical special fitures of double helix inner structure.

Conformational impact on deformation of DNA TATA-box