English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Purpose. This study investigates in silico the contribution of the hairfollicle to the overall dermal permeability of small molecules, as publishedexperimental work provides inconclusive information on whether the follicularroute favours the permeation of hydrophobic or hydrophilic permeants. Method. Astudy is conducted varying physico-chemical parameters of permeants such aslipophilicity, molecular weight and protein binding. The simulated data iscompared to published experimental data to discuss how those properties canmodulate the contribution of the hair follicle to the overall dermalpermeation. Results. The results indicate that the contribution of thefollicular route to dermal permeation can range from negligible to notabledepending on the combination of lipophilic/hydrophilic properties of thesubstance filling the follicular route and the permeant. Conclusion.Characterisation of the substance filling the follicular route is required foranalysing the experimental data of dermal permeation of small molecules, aschanges between in vivo and in vitro due to handling of samples and cessationof vital functions can modify the contribution of the follicular route tooverall dermal permeation, hence hindering data interpretation.

In silico study on the contribution of the follicular route to dermal permeability of small molecules