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Zhou et al. reported the discovery of RmYN02, a strain closely related toSARS-CoV-2, which is claimed to contain a natural PAA amino acid insertion atthe S1/S2 junction of the spike protein at the same position of the PRRAinsertion that has created a polybasic furin cleavage site in SARS-CoV-2. Theauthors support with their findings the theory that the furin cleavage siteinsertion present in SARS-CoV-2 is natural. Because no nucleotide alignmentwith closely related strains of the region coding for the supposed insertion isprovided by Zhou et al., we have applied several alignment algorithms to searchfor the most parsimonious alignments. We conclude that RmYN02 does not containan insertion at the S1/S2 junction when compared to its closest relatives atthe nucleotide level, but rather a 6-nucleotide deletion and that the claimedPAA insertion is more likely to be the result of mutations. A close examinationof RmYN02 sequencing records and assembly methods is wishful. In conclusion,SARS-CoV-2, with its 12-nucleotide insertion at the S1/S2 junction remainsunique among its sarbecovirus relatives.

The bat coronavirus RmYN02 is characterized by a 6-nucleotide deletion at the S1/S2 junction, and its claimed PAA insertion is highly doubtful