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The model of the deformation of DNA macromolecule is developed with theaccounting of two types of components of deformation: external and internal.External components describe the bend, twist and stretch of the double helix.The internal component - the conformational mobility inside of the doublehelix. In the work the deformation of DNA macromolecule is considered takinginto account the coupling of the external component (of deformation) with theinternal component (of conformational change). Under the task consideration themacromolecule twist-stretch coupling and coupling between twist and internalcomponent are taken into account. The solution obtained in these conditions forthe deformation components allows changing the character of respond in stretchcomponent on unwind (overwind) in dependence on the applied force to twistcomponent. The changing of the character of deformation from compression totension achieving of critical untwisting force (and vise versa the changing ofthe character of deformation from overwind to unwind at critical tensionforce)is known from the single molecular experiments. The nature of suchunexpected behavior of double helix have clarified in the present work byincluding in consideration the internal component. The obtained solutions andtheir conformity to experimental results show the essential role of couplingbetween internal and external components in the double helix conformationalmechanics under action force in pN range.

The effect of DNA conformation changes on the coupling of the macromolecule deformation components