English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The structure of DNA double helix is stabilized by metal counterionscondensed to a diffuse layer around the macromolecule. The dynamics ofcounterions in real conditions is governed by the electric fields from DNA andother biological macromolecules. In the present work the molecular dynamicsstudy {was} performed for the system of DNA double helix with neutralizingK$^+$ counterions and for the system of KCl salt solution in the externalelectric field of different strength (up to 32 mV/{\AA}). The analysis of ionicconductivities of these systems {has shown} that the counterions around the DNAdouble helix are slowed down compared with KCl salt solution. The calculated{values of ion mobility} are within (0.05$\div$0.4) mS/cm depending on theorientation of the external electric field relatively to the double helix.Under the electric field parallel to the macromolecule K$^+$ counterions movealong the grooves of the double helix staying longer in the places withnarrower minor groove. Under the electric field perpendicular to themacromolecule the dynamics of counterions is less affected by DNA atoms, andstarting with the electric field values about 30 mV/{\AA} the double helixundergoes a phase transition from double-stranded to single-strand state.

Dynamics of K$^+$ counterions around DNA double helix in the external electric field: a molecular dynamics study