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Substrate engineering for steering cell growth is a wide and well-establishedarea of research in the field of modern biotechnology. Here we introduce amicromachining technique to pattern an inert, transparent polymer matrixblended with a photoactive polymer. We demonstrate that the obtained scaffoldcombines the capability to align with that to photostimulate living cells. Thistechnology can open up new and promising applications, especially where cellalignment is required to trigger specific biological functions, e.g. generatepowerful and efficient muscle contractions following an external stimulus.

A Polymer Blend Substrate for Skeletal Muscle Cells Alignment and Photostimulation