English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Purpose: Explaining why 90Y TOF-PET based equivalent uniform dose (EUD) usingstandard FDG reconstruction parameters has been shown to predict response.  Methods: The hot rods insert of a Jaszczak deluxe phantom was partiallyfilled with a 2.65 GBq 90Y - 300ml DTPA water solution resulting in a 100 Gymean absorbed dose in the 6 sectors. A two bed 20min/position acquisition wasperformed on a 550ps- and on a 320ps- TOF-PET/CT and reconstructed withstandard FDG reconstruction parameters, without and with additional filtering.The whole procedure was repeated on both PET after adding a 300ml of water(50Gy setup). The phantom was acquired again after decay by a factor 10 (5Gysetup), but with 200min per bed position. For comparison the phantom was alsoacquired with 18F activity corresponding to a clinical FDG whole bodyacquisition.  Results: The 100Gy-setup provided hot rod sectors image almost as good as in18F phantom. However, despite acquisition time compensation the 5Gy-setupprovides much lower quality imaging. TOF-PET based sectors EUDs for the threelarge rod sectors were in agreement with the actual EUDs computed with aradiosensitivity 0.021Gy-1 well in the range observed in external beamradiotherapy (EBRT), i.e. 0.01-0.04Gy-1. This agreement explains thereunification of the dose-response relationships of the glass and resin spheresin HCC using the TOF-PET based EUD. Additional filtering reduced the EUDsagreement quality.  Conclusions: Standard FDG reconstruction parameters are suitable in TOF-PETpost 90Y liver radioembolization for accurate tumor EUD computation. Thepresent results clearly rules out the use of low specific activity phantomstudies to optimize reconstruction parameters.

Yttrium-90 TOF-PET based EUD predicts response post liver radioembolizations using standard manufacturer reconstruction parameters