English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Motivated by a clinical trial conducted by Janssen Pharmaceuticals in which aflexible dosing regimen is compared to placebo, we evaluate how switchers inthe treatment arm (i.e., patients who were switched to the higher dose) wouldhave fared had they been kept on the low dose. This in order to understandwhether flexible dosing is potentially beneficial for them. Simply comparingthese patients' responses with those of patients who stayed on the low dose isunsatisfactory because the latter patients are usually in a better healthcondition. Because the available information in the considered trial is tooscarce to enable a reliable adjustment, we will instead transport data from afixed dosing trial that has been conducted concurrently on the same target,albeit not in an identical patient population. In particular, we will proposean estimator which relies on an outcome model and a propensity score model forthe association between study and patient characteristics. The proposedestimator is asymptotically unbiased if at least one of both models iscorrectly specified, and efficient (under the model defined by the restrictionson the propensity score) when both models are correctly specified. We show thatthe proposed method for using results from an external study is genericallyapplicable in studies where a classical confounding adjustment is not possibledue to positivity violation (e.g., studies where switching takes place in adeterministic manner). Monte Carlo simulations and application to themotivating study demonstrate adequate performance.

Efficient, Doubly Robust Estimation of the Effect of Dose Switching for Switchers in a Randomised Clinical Trial