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In this work, we present a paradigm bridging electromagnetic (EM) andmolecular communication through a stimuli-responsive intra-body model. It hasbeen established that protein molecules, which play a key role in governingcell behavior, can be selectively stimulated using Terahertz (THz) bandfrequencies. By triggering protein vibrational modes using THz waves, we inducechanges in protein conformation, resulting in the activation of a controlledcascade of biochemical and biomechanical events. To analyze such aninteraction, we formulate a communication system composed of a nanoantennatransmitter and a protein receiver. We adopt a Markov chain model to accountfor protein stochasticity with transition rates governed by the nanoantennaforce. Both two-state and multi-state protein models are presented to depictdifferent biological configurations. Closed form expressions for the mutualinformation of each scenario is derived and maximized to find the capacitybetween the input nanoantenna force and the protein state. The results weobtain indicate that controlled protein signaling provides a communicationplatform for information transmission between the nanoantenna and the proteinwith a clear physical significance. The analysis reported in this work shouldfurther research into the EM-based control of protein networks.

Information Rates of Controlled Protein Interactions Using Terahertz Communication