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Recurrent respiratory symptoms are common in infants but the paucity of lungfunction tests suitable for routine use in infants is a widely acknowledgedclinical problem. In this study we evaluated tidal breathing variability(expiratory variability index, EVI) measured at home during sleep usingimpedance pneumography (IP) as a marker of lower airway obstruction in 36infants (mean age 12.8 [range 6-23] months) with recurrent respiratorysymptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higherasthma risk, and obstructive symptoms, but not with nasal congestion. EVImeasured using IP is a potential technique for lung function testing ininfants.

Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms