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Understanding and modelling the complexity of the immune system is achallenge that is shared by the ImmunoComplexiT$^1$ thematic network from theRNSC. The immune system is a complex biological, adaptive, highly diversified,self-organized and degenerative cognitive network of entities, allowing for arobust and resilient system with emergent properties such as anamnesticresponses and regulation. The adaptive immune system has evolved into a complexsystem of billions of highly diversified lymphocytes all interacting as aconnective dynamic, multi-scale organised and distributed system, in order tocollectively insure body and species preservation. The immune system ischaracterized by complexity at different levels: network organisation throughfluid cell populations with inter-and intra-cell signalling, lymphocytereceptor diversity, cell clonotype selection and competition at cell level,migration and interaction inside the immunological tissues and fluiddissemination through the organism, homeostatic regulation while rapidadaptation to a changing environment.

Understanding and Modelling the Complexity of the Immune System: Systems  Biology for Integration and Dynamical Reconstruction of Lymphocyte  Multi-Scale Dynamics