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Transport of intracellular cargo is often mediated by teams of molecularmotors that function in a chaotic environment under varying conditions. We showthat the motors have unique steady state behavior which enables transportmodalities that are robust. Under reduced ATP concentrations, multi-motorconfigurations are preferred over single motors. Higher load force drivesmotors to cluster, but very high loads compel them to separate in a manner thatpromotes immediate cargo movement once the load subsides. These inferences,backed by analytical guarantees, provide unique insights into the coordinationstrategies adopted by molecular motors to transport intracellular cargo.

Hindering loads prompt clustered configurations that enhance stability during cargo transport by multiple Kinesin-1