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Multi-step assembly of individual protein building blocks is key to theformation of essential higher-order structures inside and outside of cells.Optical tweezers is a technique well suited to investigate the mechanics anddynamics of these structures at a variety of size scales. In this mini-review,we highlight experiments that have used optical tweezers to investigate proteinassembly and mechanics, with a focus on the extracellular matrix proteincollagen. These examples demonstrate how optical tweezers can be used to studymechanics across length scales, ranging from the single-molecule level tofibrils to protein networks. We discuss challenges in experimental design andinterpretation, opportunities for integration with other experimentalmodalities, and applications of optical tweezers to current questions inprotein mechanics and assembly.

Optical tweezers approaches for probing multiscale protein mechanics and assembly