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Microtubule (MT) radial arrays or asters establish the internal topology of acell by interacting with organelles and molecular motors. We proceed tounderstand the general pattern forming potential of aster-motor systems using acomputational model of multiple MT asters interacting with motors in a cellularconfinement. In this model dynein motors are attached to the cell cortex andplus-ended motors resembling kinesin-5 diffuse in the cell interior. Theintroduction of 'noise' in the form of MT length fluctuations spontaneouslyresults in the emergence of coordinated, achiral vortex-like rotation ofasters. The coherence and persistence of rotation requires a threshold densityof both cortical dyneins and coupling kinesins, while the onset of rotation ifdiffusion-limited with relation to cortical dynein mobility. The coordinatedrotational motion arises due to the resolution of the 'tug-of-war' of therotational component due to cortical motors by 'noise' in the form of MTdynamic instability, and such transient symmetry breaking is amplified by localcoupling by kinesin-5 complexes. The lack of widespread aster rotation acrosscell types suggests biophysical mechanisms that suppress such intrinsicdynamics may have evolved. This model is analogous to more general models oflocally coupled self-propelled particles (SPP) that spontaneously undergocollective transport in presence of 'noise' that have been invoked to explainswarming in birds and fish. However, the aster-motor system is distinct fromSPP models with regard to particle density and 'noise' dependence, providing aset of experimentally testable predictions for a novel sub-cellular patternforming system.

Aster Swarming by Collective Mechanics of Dyneins and Kinesins