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Crohn's disease and ulcerative colitis, both under the umbrellaof inflammatory bowel diseases (IBD), involve many distinct molecularprocesses. The difference in their molecular processes is studied by using thedifferent genes involved in each disease, and it is explored further for drugtargeting and drug repurposing. Methods: The initial set of genes was obtainedby mining published literature and several curated databases. The identifiedgenes were then subject to Systems and Network analysis to reveal theirmolecular processes and shed some light on their pathogenesis. Suchmethodologies have identified newer targets and drugs that can be repurposed.Results: We use a Systems and Network Medicine approach to understand themechanism of actions of genes involved in IBD. From an initial set of genesmined from literature and curated databases, we used the Multi-Steiner Treealgorithm implemented within the CoVex systems medicine platform to expand eachdisease module by incorporating candidate genes with significant connections tothe disease-related seed genes. Such expanded disease modules will identify alarger set of potential targets and drugs. We used the Closeness Centralityalgorithm implemented within CoVex to search for newer targets and repurposabledrugs. Through a network medicine approach, we provide a mechanistic view ofthe diseases and point to newer drugs and targets. Conclusion: We demonstratethat the Systems and Network Medicine approach is a powerful way to understanddiseases and understand their mechanisms of action.

In Search of Newer Targets for IBD: A Systems and a Network Medicine Approach