English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The use of glass for pharmaceutical new applications such as high-technologydrugs, requires the strictest container inertness. A common theme of paramountimportance in glass container integrity preservation is the detailed mechanismdriving the sudden failure due the crack propagation. Using a combination ofDiscrete Element Method (DEM) and Finite Element Method (FEM), a stress map forglass cartridges packed into an accumulation table and transported by aconveyor belt at a fixed velocity is obtained under realistic conditions. TheDEM calculation provides a full description of the dynamics of the cartridges,as approximated by an equivalent sphere, as well as the statistics of themultiple collisions. The FEM calculation exploits this input to provide themaximum principal stress of different pairs as a function of time. Our analysisshows that, during their transportation on the conveyor belt, the cartridgesare subject to several shocks of varying intensities. Under these conditions, acrack may originate inside the cartridge in the area of maximal tensile stress,and propagate outward. Estimated stresses are found in good agreement with realsystems.

An integrated DEM-FEM approach to study breakage in packing of glass cartridges on a conveyor belt