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Abnormalities within cells result in nanoscale structural alterations can becharacterized via confocal imaging and quantification of these alterations.Accidental or deliberate exposure to total body irradiation (TBI) have adverseeffects on the nuclear DNAs of cells. Here, we study the DNA molecular massdensity spatial structural alterations of chromatin in cell nuclei of guttissues caused by the exposure to standard doses of 4Gy TBI, using the lightlocalization technique called inverse participation ratio (IPR) in confocalimages. Results indicate radiation suppresses DNA spatial mass densityfluctuations. And hence, reduction and saturation in DNA density fluctuationsare observed for different durations of post-irradiation.

Photonics probing of DNA specific spatial mass density fluctuations in gut cell nuclei due to total body irradiation via confocal imaging