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In pathology protocols, each tissue block can generate a large number ofsections making it impractical to analyze every section. X-ray microscopy thatprovides a rapid survey of intact tissue blocks can help pinpoint the relevantstructures in 3D space for subsequent analysis, and thus reduce workload andenable further automation downstream. Unlike dedicated virtual histologystudies by traditional micro computed tomography (CT), routine scout imaging isconstrained by a time window of minutes and minimal sample handling to avoidinterfering with the pathology protocols. Traditional micro CT was not able tomeet the requirements due to lengthy study times or sample alteration by theintroduction of x-ray contrast agents. A form of x-ray tomosynthesis used insecurity screening was found to be efficient for rapid microscopy of unstainedsamples. When compared to a commercial micro CT scanner, it provided a 10-foldincrease in imaging speed and a 4.8-fold increase in contrast-to-noise ratio.We report the results from a variety of human and animal tissue samples, whereit served as an integral step of pathology protocols. In cases of vasculardisease, it provided quantitative measurements of calcification in intactsamples, which were difficult to obtain by standard pathology procedures. Theprospect of continuous and automated screening of many samples in anassembly-line approach is discussed.

TSA-inspired micro tomosythesis scanner for rapid scouting of histopathology samples