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Cellular decision making allows cells to assume functionally differentphenotypes in response to microenvironmental cues, without genetic change. Itis an open question, how individual cell decisions influence the dynamics atthe tissue level. Here, we study spatio-temporal pattern formation in apopulation of cells exhibiting phenotypic plasticity, which is a paradigm ofcell decision making. We focus on the migration/resting and themigration/proliferation plasticity which underly the epithelial-mesenchymaltransition (EMT) and the go or grow dichotomy. We assume that cells changetheir phenotype in order to minimize their microenvironmental entropy (LEUP:Least microEnvironmental Uncertainty Principle) and study the impact of theLEUP-driven migration/resting and migration/proliferation plasticity on thecorresponding multicellular spatio-temporal dynamics with a stochasticcell-based mathematical model for the spatio-temporal dynamics of the cellphenotypes. In the case of the go or rest plasticity, a correspondingmean-field approximation allows to identify a bistable switching mechanismbetween a diffusive (fluid) and an epithelial (solid) tissue phase whichdepends on the sensitivity of the phenotypes to the environment. For the go orgrow plasticity, we show the possibility of Turing pattern formation for the"solid" tissue phase and its relation with the parameters of the LEUP-drivencell decisions.

Entropy-driven cell-decision making predicts fluid-to-solid transition in multicellular systems