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Subtle changes in Raman spectral line-shape have been observed from malignanthuman brain cells and its possibility for being used in detection and gradingof Glioma has been explored here. The latter has been developed as a result ofthe fact that the width of the Raman spectra is more sensitive, as compared tothe peak position, to the brain tumors. The perturbations induced by thecell-modification, as a consequence to the cancerous growth, may be responsiblefor the widths variation in the Raman spectrum due to vibrational lifetimealteration enforced at the molecular levels. A consistent cancer induced effecton the spectral width has been observed for three different brain cells Ramanmodes at different frequencies . Raman spectral analysis reveals that forcancerous cells, the FWHM varies up to 35 % in comparison with the healthycells. It has been established how a careful analysis of Raman spectra can helpin easy detection of brain tumors. The methodology has been validated bystudying the effect of similar microscopic perturbations, e.g, Fano couplingand quantum size effects, on different Raman spectral parameters which alsoreveals Raman width to be the most sensitive parameter.

Malignancy Induced Subtle Perturbation Sensitive Raman Scattering for Glioma Detection and Grading