English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

2019-nCoV is a novel coronavirus was isolated and identified in 2019 inWuhan, China. On 17th February and according to world health organization, anumber of 71 429 confirmed cases worldwide, among them 2162 new cases recordedin the last 24 hours. There is no drug or vaccine for human and animalcoronavirus. The inhibition of 3CL hydrolase enzyme provides a promisingtherapeutic principle for developing treatments against CoViD-19. The 3CLpro(Mpro) known for involving in counteracting the host innate immune response.This work presents the inhibitory effect of some natural compounds against 3CLhydrolase enzyme, and explain the main interactions in inhibitor-enzymecomplex. Molecular docking study carried out using Autodock Vina. By screeningseveral molecules, we identified three candidate agents that inhibit the mainprotease of coronavirus. Hispidin, lepidine E, and folic acid bound tightly inthe enzyme, strong hydrogen bonds have been formed (1.69-1.80&[Aring]) with theactive site residues. This study provides a possible therapeutic strategy forCoViD-19.

Hispidin and Lepidine E: two Natural Compounds and Folic acid as  Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro),  molecular docking and SAR study