English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The fatality rate of Covid-19 escalates with age and is larger in men thanwomen. I show that these variations correlate strongly with the level of theviral receptor protein ACE2 in rat lungs, which is consistent with the stilllimited and apparently contradictory data on human ACE2. Surprisingly, lowerlevels of the receptor correlate with higher fatality. However, a previousmathematical model predicts that the speed of viral progression in the organismhas a maximum and then declines with the receptor level. Moreover, manymanifestations of severe CoViD-19, such as severe lung injury, exacerbatedinflammatory response and thrombotic problems may derive from increasedAngiotensin II (Ang-II) level that results from degradation of ACE2 by thevirus. I present here a mathematical model based on the influence of ACE2 onviral propagation and disease severity. The model fits Covid-19 fatality rateacross age and sex with high accuracy ($r^2>0.9$) under the hypothesis thatSARS-CoV-2 infections are in the dynamical regimes in which increased receptorslows down viral propagation. Moreover, rescaling the model parameters by theratio of the binding rates of the spike proteins of SARS-CoV and SARS-CoV-2allows predicting the fatality rate of SARS-CoV across age and sex, thuslinking the molecular and epidemiological levels. The presented model opposesthe fear that angiotensin receptor blockers (ARB), suggested as a therapyagainst the most adverse effects of CoViD-19, may favour viral propagation, andsuggests that Ang-II and ACE2 are candidate prognostic factors for detectingpopulation that needs stronger protection.

Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19  lethality across age and sex and predicts that of SARS, supporting possible  therapy