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Absent a drug or vaccine, containing epidemic outbreaks is achieved by meansof social distancing, specifically mobility restrictions and lock-downs. Suchmeasures impose a hurtful toll on the economy, and are difficult to sustain forextended periods. As an alternative, we propose here an alternating quarantinestrategy, in which at every instance, half of the population remains underlock-down while the other half continues to be active, maintaining a routine ofweekly succession between activity and quarantine. This regime affords a dualpartition:\ half of the population interacts for only half of the time,resulting in a dramatic reduction in transmission, comparable to that achievedby a population-wide lock-down. All the while, it enables socioeconomiccontinuity at $50\%$ capacity. The proposed weekly alternations also address anadditional challenge, with specific relevance to COVID-19. Indeed, SARS-CoV-2exhibits a relatively long incubation period, in which individuals experienceno symptoms, but may already contribute to the spread. Unable to selectivelyisolate these invisible spreaders, we resort to population-wide restrictions.However, under the alternating quarantine routine, if an individual was exposedduring their active week, by the time they complete their quarantine they will,in most cases, begin to exhibit symptoms. Hence this strategy isolates themajority of pre-symptomatic individuals during their infectious phase, leadingto a rapid decline in the viral spread, thus addressing one of the mainchallenges in COVID-19 mitigation.

Alternating quarantine for sustainable epidemic mitigation