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Coronaviruses have recently caused world-wide severe outbreaks: SARS (SevereAcute Respiratory Syndrome) in 2002 and MERS (Middle-East Respiratory Syndrome)in 2012. At the end of 2019, a new coronavirus outbreak appeared in Wuhan(China) seafood market as first focus of infection, becoming a pandemics in2020, spreading mainly into Europe and Asia. Although the virus family iswell-known, this specific virus presents considerable differences, as highertransmission rates, being a challenge for diagnostic methods, treatments andvaccines. Coronavirus(C++).pro is a C++ application which simulates Coronavirusreplication cycle. This software has identified virus type in short times andprovided FASTA files of virus proteins, a list of mRNA sequences and secondarystructures. Furthermore, the software has identified a list of structural,non-structural and accessory proteins in 2019-nCoV virus genome more similar toSARS than to MERS, as several fusion proteins characteristics of this virustype. These results are useful as a first step in order to develop diagnosticmethods, new vaccines or antiviral drugs, which could avoid virus replicationin any stage: fusion inhibitors, RdRp inhibitors and PL2pro/3CLpro proteaseinhibitors.

Coronavirus SARS-CoV-2: Analysis of subgenomic mRNA transcription, 3CLpro and PL2pro protease cleavage sites and protein synthesis