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Corneal evaluation in ophthalmology necessitates cellular-resolution and fastimaging techniques allowing accurate diagnoses. Currently, the fastestvolumetric imaging technique is Fourier-domain full-field optical coherencetomography (FD-FF-OCT) that uses a fast camera and a rapidly tunable lasersource. Here, we demonstrate high-resolution, high-speed, non-contact cornealvolumetric imaging in vivo with FD-FF-OCT that can acquire a single 3D volumewith a voxel rate of 7.8 GHz. The spatial coherence of the laser source wassuppressed to prevent it from focusing to a spot on the retina, and therefore,exceeding the maximum permissible exposure (MPE). Inherently volumetric natureof FD-FF-OCT data enabled flattening of curved corneal layers. AcquiredFD-FF-OCT images revealed corneal cellular structures, such as epithelium,stroma and endothelium, as well as subbasal and mid-stromal nerves.

In vivo imaging of human cornea with high-speed and high-resolution Fourier-domain full-field optical coherence tomography