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We investigate the possible influence of poly unsaturated fatty acids (PUFAs)in the lipid bilayer of cell membranes on the conduction properties of theselectivity filter of voltage gated ion channels. Any change of thisconductivity can have major consequences on electrical signalling in brain andother cells. At the microscopic level a change in the concentration of PUFAscan cause a change in the pressure distribution within the lipid bilayer, andthis in turn can lead to a change in the length of the selectivity filter. Inorder to estimate the consequences this might entail for the ion channel'sconductivity we performed high resolution molecular dynamics (MD) simulationsof the passage of K+ ions and H2O molecules through the selectivity filter ofthe KcsA potassium ion channel. Our results show that a change in length of theselectivity filter of as little as 4%, independent of whether the filter ismade longer or shorter, will reduce the K+ ion current by around 50%. Andfurther squeezing or stretching by about 10% can effectively stop the current.For instructive purposes and to facilitate further interpretation of theresults, we give details of the force models employed in the MD simulations. Wefinally discuss the present results in the context of possible effects ofmembrane lipid compositions on Kv ion permeation.

Forces from Lipids and Ionic Diffusion: Probing lateral membrane effects by an optimized filter region of voltage dependent K+ channels