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It is possible that there are post-translational circadian oscillators thatcontinue functioning in the absence of negative feedback transcriptionalrepression in many cell types from diverse organisms. Apart from the KaiABCsystem from cyanobacteria, the molecular components and interactions requiredto create in-vitro ("test-tube") circadian oscillations in different cell typesare currently unknown. Inspired by the KaiABC system, I provide"proof-of-principle" mathematical models that a protein with 2 (or more)modification sites which selectively sequesters an effector/cofactor moleculecan function as a circadian time-keeper. The 2-site mechanism can beimplemented using two relatively simple coupled non-linear ODEs in terms ofsite occupancy; the models do not require overly special fine-tuning ofparameters for generating stable limit cycle oscillations.

Simple post-translational circadian clock models from selective sequestration