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In this paper, it is first discovered that EcN has natural magneticallycontrolled properties, that is, E coli Nissle 1917 cells move in a gradientmagnetic field of permanent magnets without artificial magnetic labeling. It isalso shown in the paper that the cultivation of EcN in a medium enriched withiron chelates and under the influence of an external magnetic field increasesseveral times the magnetophoretic mobility of E coli Nissle 1917 cells comparedto cultivation under standard conditions. Thus, the speed of movement of E coliNissle 1917 cells in a gradient magnetic field of laboratory magnets isachieved of the order of several mm/s. It has also been shown for the firsttime that the cultivation of E coli Nissle 1917 biomass is accelerated bycultivation in an external magnetic field, while the change in theconcentration of iron chelates in the medium has no effect on the cultivationdynamics of the E coli Nissle 1917 culture.

Magnetically controlled vector based on E coli Nissle 1917