English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

OBJECTIVE: To design and evaluate new pharmacogenomic (PGx) clinical decisionsupport (CDS) alerts, built to adhere to PGx CDS design principles developedthrough socio-technical approaches.  MATERIALS AND METHODS: Based on previously identified design principles, wecreated 11 new PGx CDS alert designs and developed an interactive webapplication containing realistic clinical scenarios and user workflows thatmimicked a real-world EHR system. We recruited General Internal Medicine andCardiology clinicians from Northwestern Medicine and recorded theirinteractions with the original and new designs. We measured clinician response,satisfaction, speed, and confidence through questionnaires and analysis of therecordings.  RESULTS: The study included 12 clinicians. Participants were significantlymore satisfied (p=0.1), faster (p=0.009), and more confident (p<.05) withthe new designs than the original ones. The study lacked statistical power todetermine whether prescribing accuracy was improved, but participants were noless accurate, and clinical actions were more concordant with alertinteractions (p=0.004) with the new designs. We found a significant learningcurve associated with the original designs, which was eliminated with the newdesigns.  DISCUSSION: This study successfully demonstrates that socio-technical anduser-centered design techniques can improve PGx CDS alert designs. Bestpractices for PGx CDS design are limited in the literature, with feweffectiveness studies available. These results can help guide future PGx CDSimplementations to be more clinician friendly and less time-consuming.  CONCLUSION: The results of this study support the PGx CDS design principleswe proposed in previous work. As a next step, the new designs should beimplemented in a live setting for further validation.

Design Principles Developed through User-Centered and Socio-Technical  Methods Improve Clinician Satisfaction, Speed, and Confidence in  Pharmacogenomic Clinical Decision Support