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To understand mechanism of cell-membrane compartmentalization, we studiedcoarse-grained model systems consisting of lipid and cholesterol molecules.Cholesterol plays crucial role in lateral phase segregation in the bilayeredlipid membrane to form cholesterol rich liquid ordered domains, termed as`rafts'. In this NVT Molecular Dynamics simulation study, we have investigatedthe role of cholesterol in raft-like domain formation. The study reveals thatthe strength of cholesterol interaction is an important factor behind the phasesegregation to form cholesterol rich domains, whereas, the relative dipolarstrength of lipid and cholesterol molecules controls the formation ofmulti-bilayered stack.

Raft-like domain formation in model lipid-cholesterol aggregation