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Stochasticity (or noise) at cellular and molecular levels has been observedextensively as a universal feature for living systems. However, how livingsystems deal with noise while performing desirable biological functions remainsa major mystery. Regulatory network configurations, such as their topology andtimescale, are shown to be critical in attenuating noise, and noise is alsofound to facilitate cell fate decision. Here we review major recent findings onnoise attenuation through regulatory control, the benefit of noise vianoise-induced cellular plasticity during developmental patterning, andsummarize key principles underlying noise control.

Noise control and utility: from regulatory network to spatial patterning