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Transcriptomics, regional cerebral blood flow (rCBF), and a spatial motorvirtual reality task were integrated using mediation analysis in a noveldemonstration of "imaging omics". Data collected in NCAA Division I footballathletes cleared for play before in-season training showed significantrelationships in a) elevated levels of miR-30d and miR-92a to elevated putamenrCBF, (b) elevated putamen rCBF to compromised balance scores, and (c)compromised balance scores to elevated miRNA levels. rCBF acted as a mediatorvariable (minimum 70% mediation, significant Sobel's test) between abnormalmiRNA levels and compromised balance scores. Given the involvement of thesemiRNAs in inflammation and immune function, and that vascular perfusion is acomponent of the inflammatory response, these findings support a chronicinflammatory model of repetitive head acceleration events (HAEs). rCBF, asystems biology measure, was necessary for miRNA to affect behavior. Theseresults suggest miRNA as a potential diagnostic biomarker for repetitive HAEs.

Brain perfusion mediates the relationship between miRNA levels and postural control