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3-demensional (3D) culture model is a valuable in vitro tool to study liverbiology, metabolism, organogenesis, tissue morphology, drug discovery andcell-based assays. Compelling evidence suggests that cells cultured in 3D modelexhibit superior liver-specific functions over the conventional 2-dimentional(2D) culture in evaluating hepatobiliary drug disposition and drug-inducedhepatotoxicity due to the in vivo-like physiological condition recapitulated by3D model technologies. We will review the attributes of 3D culture model inacquiring relevant liver phenotypes and functionalities, discuss the criticalniche factors found to modulate hepatocytes and highlight recent advancementson 3D cell culture technologies to achieve next-level in vitro tool forpreclinical study.

Three-dimensional cell culture model for hepatocytes opens a new avenue of real world research on liver